Fathi Halaweish's Research

Design and synthesis of C-11-substituted estrone analogs for treatment of pancreatic cancer: C-11-substituted estrone analogs provide increased cytotoxicity towards both 2-dimensional and 3-dimensional cell cultures in vitro. Recent work has focused on analogs with oxygenated and nitrogenous functionality.
Design and synthesis of fluorine-substituted aromatic estrone analogs for prostate cancer: Substitution of aromatic steroids with fluorine to increase binding to kinases involved in cell survival, namely the Epidermal Growth Factor Receptor (EGFR) pathway.
Synthetic optimization for substituted C23-C24 enone analogs for use in hepatocellular carcinoma: estrone analogs possess a potential flaw in that they exhibit the ability to act as Michael Acceptors for conjugation addition. This could lead to fast metabolism and removal from the body, and as such, is being investigated by exploring the ability to substitute the enone system with fluorine and nitrile functionalization.

Recent Publications

Department of Chemistry, Biochemistry and Physics

Physical Address

1066 Campanile Ave.

Brookings, SD 57007

Mailing Address

SAV 247, Box 2202

Brookings, SD 57007

Hours

Mon - Fri: 8:00 a.m.-5:00 p.m.

605-688-5151

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