Recent Publications
Kong L, Saha S, Hu Y, Tschetter JN, Habben CE, Whitmore LS, Yao C, Ge X, Ye P, Newkirk SJ, An W. Subfamily-specific differential contribution of individual monomers and the tether sequence to mouse L1 promoter activity. Mobile DNA, 13 (2022). PMID: . PMCID: . DOI: . Posted December 04, 2021 on (initial version)
Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, Wylie A, Newkirk SJ, Jones AE, Lee M Jr., Botten GA, Deng M, Dickerson KE, Zhang CC, An W, Abrams JM, & Xu J. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Nature Genetics, 53:672–682 (2021). PMID: . PMCID: . DOI:
Newkirk SJ, Kong L, Jones MM, Habben CE, Dilts VL, Ye P, & An W. Subfamily-specific quantification of endogenous L1 retrotransposons by droplet digital PCR. Analytical Biochemistry, 601:113779 (2020). PMID: . PMCID: . DOI:
Liu R, Sreenivasan C, Yu H, Sheng Z, Newkirk SJ, An W, Smith DF, Chen X, Wang D, & Li F. Influenza D virus diverges from its related influenza C virus in the recognition of 9-O-acetylated N-acetyl- or N-glycolyl-neuraminic acid-containing glycan receptors. Virology, 545:16-23 (2020). PMID: . PMCID: . DOI:
Newkirk SJ, & An W. UHRF1: a jack of all trades, and a master epigenetic regulator during spermatogenesis. Biology of Reproduction, 102:1147-1152 (2020). PMID: . PMCID: . DOI:
Ray DA, Paulat N, An W, Boissinot S, Cordaux R, Kaul T, Freeman B, & Belancio V. The 2019 FASEB Science Research Conference on The Mobile DNA Conference: 25 Years of Discussion and Research, June 23–28, Palm Springs, California, USA. FASEB Journal, 33(11):11625-11628 (2019). PMID: . DOI:
Vazquez BN, Thackray JK, Simonet N, Chahar S, Kane-Goldsmith N, Newkirk SJ, Lee S, Xing J, Verzi MP, An W, Vaquero A, Tischfield JA, & Serrano L. SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina. Nucleic Acids Research, 47:7870–7885 (2019). PMID: . PMCID: . DOI:
Wang Z, McSwiggin H, Newkirk SJ, Wang Y, Oliver D, Tang C, Lee S, Wang S, Yuan S, Zheng H, Ye P, An W, & Yan W. Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype. Mobile DNA, 10:17 (2019). PMID: . PMCID: . DOI:
Saha P, & An W. Recently Mobilized Transposons in the Human Genome. In: . John Wiley & Sons Ltd, Chichester. (2019). DOI: 10.1002/9780470015902.a0020837 ()
Reznik B, Cincotta SA, Jaszczak RG, Mateo LJ, Shen J, Cao M, Baskin L, Ye P, An W, & Laird DJ. Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells. Development 146(12):dev171157 (2019). PMID: . PMCID: . DOI:
Kawano K, Doucet AJ, Ueno M, Kariya R, An W, Marzetta F, Kuroki M, Turelli P, Sukegawa S, Okada S, Strebel K, Trono D, & Ariumi Y. HIV-1 Vpr and p21 restrict LINE-1 mobility. Nucleic Acids Research 46:8454–8470 (2018). PMID: . PMCID: . DOI:
Sheng Z, Liu R, Yu J, Ran Z, Newkirk SJ, An W, Li F, & Wang D. Identification and characterization of viral defective RNA genomes in influenza B virus. Journal of General Virology 99(4):475-488 (2018). PMID: . PMCID: . DOI:
Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, & An W. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A 114:E5635–E5644 (2017). PMID: . PMCID: . DOI: . Commented by: Wang PJ. . Proc Natl Acad Sci U S A 114:7194–7196 (2017). Highlighted by: Chen C. . Biology of Reproduction 97:335-336 (2017)
Kannan M, Li J, Fritz SE, Husarek KE, Sanford JC, Sullivan TL, Tiwary PK, An W, Boeke JD, & Symer EE. Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration. Mobile DNA 8:8 (2017). PMID: . PMCID: . DOI:
Newkirk SJ, & An W. L1 Regulation in Mouse and Human Germ Cells. in , ed Cristofari G (Springer International Publishing), pp 29-61 (2017). DOI: (PDF )
Kharytonchyk S, King SR, Ndongmo CB, Stilger KL, An W, & Telesnitsky A. Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication. Journal of Molecular Biology. 428:2275–2288 (2016). PMID: . PMCID: . DOI: .
Grandi FC, Rosser JM, Newkirk SJ, Yin J, Jiang X, Xing Z, Whitmore L, Bashir S, Ivics Z, Izsvák Z, Ye P, Yu YE, & An W. Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites. Genome Research. 25:1135-1146 (2015). PMID: . PMCID: . DOI: .
Grandi FC, & An W. Non-LTR retrotransposons and microsatellites: Partners in genomic variation. Mobile Genetic Elements. 3:e25674 (2013). PMID: . PMCID: . DOI: .
O'Donnell KA, An W, Schrum CT, Wheelan SJ, & Boeke JD. Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model. Proc Natl Acad Sci U S A 110:E2706-13 (2013). PMID: . PMCID: . DOI: .
Xie Y, Mates L, Ivics Z, Izsvák Z, Martin SL, & An W. Cell division promotes efficient retrotransposition in a stable L1 reporter cell line. Mobile DNA. 4:10 (2013). PMID: . PMCID: . DOI:
Grandi FC, Rosser JM, & An W. LINE-1 derived poly(A) microsatellites undergo rapid shortening and create somatic and germline mosaicism in mice. Molecular Biology and Evolution. 30:503-12 (2013). PMID: . PMCID: . DOI: .
Ray D, Hogarth CA, Evans EB, An W, Griswold MD, & Ye P. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Biology of Reproduction 86(4):102 (2012). PMID: . PMCID: . DOI:
Rosser JM, & An W. L1 expression and regulation in humans and rodents. . PMID: . PMCID: .
An W, Dai L, Niewiadomska AM, Yetil A, O'Donnell KA, Han JS, & Boeke JD. Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs. Mobile DNA. 2:2 (2011). PMID: . PMCID: . DOI: .
Xie Y, Rosser JM, Thompson TL, Boeke JD, & An W. Characterization of L1 retrotransposition with high-throughput dual-luciferase assays. Nucleic Acids Research 39, e16 (2011). PMID: . PMCID: . DOI: .
Rosser JM, & An W. Repeat-induced gene silencing of L1 transgenes is correlated with differential promoter methylation. Gene 456, 15-23 (2010). PMID: . PMCID: . DOI: .
An W, Davis ES, Thompson TL, O'Donnell KA, Lee C-Y, & Boeke JD. Plug and play modular strategies for synthetic retrotransposons. Methods 49, 227-35 (2009). PMID: . PMCID: . DOI: .
Han Y, Lin YB, An W, Xu J, Yang HC, O'Connell K, Dordai D, Boeke JD, Siliciano JD, & Siliciano RF. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4, 134-46 (2008). PMID: . PMCID: . DOI: .
An W, Han JS, Schrum CM, Maitra A, Koentgen F, & Boeke JD. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46, 373-83 (2008). PMID: . PMCID: . DOI: .
Boeke JD, An W, Dai L, Davis ES, Han, JS, O'Donnell KA, Scheifele LZ, & Wheelan, S.J. . doi:10.1007/978-3-540-74966-0_3. ISBN: 978-3-540-74965-3 (Print) 978-3-540-74966-0 (Online)
An W, Han JS, Wheelan SJ, Davis ES, Coombes CE, Ye P, Triplett C, & Boeke JD. Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A 103, 18662-7 (2006). PMID: . PMCID: . DOI: .
An W, & Boeke JD. Transposon technology and vertebrate functional genomics. Genome Biology 6, 361 (2005). PMID: . PMCID: . DOI: .