Adam Hoppe
Professor
Biography
Dr. Adam Hoppe is a professor of chemistry, biochemistry and physics. He is research focuses on elucidating how antibodies activate functions in the macrophage, a key immune cell. To this end, he develops new biophysical, molecular and genetic methods to understand how macrophages consume and degrade other cells within the body, a process known as phagocytosis. His lab is working to improve antibody and cytokine immunotherapies that act through phagocytosis. This work aims to improve treatments for cancer, autoimmune and viral diseases. Dr. Hoppe is the inaugural director of SDSU’s first National Institutes of Health Center of Biomedical Research Excellence focused on inflammation and immunology. In this role, he supports the mentorship of faculty developing nationally recognized biomedical research programs as well as expansion of research core facilities for biomedical and biological research.
Education
- Ph.D. in biophysics | University of Michigan | 2003
- M.S. in medical physics | University of Wisconsin-Madison | 1999
- B.A. in physics and mathematics, minor in chemistry | Concordia College | 1997
Academic and Professional Experience
Academic Responsibilities
- 2022 – National Institutes of Health Center of Biomedical Research Excellence, Brookings, South à£à£Ö±²¥Ðã
- Director – BioSystems Networks and Transformative Research-Insights into Inflammation (BioSNTRii)
- 2021-2022 – South à£à£Ö±²¥Ðã State University, Brookings, South à£à£Ö±²¥Ðã
- Interim associate dean for research
Research and Scholarly Work
Areas of Research
- Macrophage immune regulation and function
- Fc{gamma} receptor signaling
- Membrane and receptor biophysics
- Antibody-dependent cellular phagocytosis
- Advanced optical microscopy methods
- Whole genome CRISPR screening and transcriptomic analysis
à£à£Ö±²¥Ðãs and Honors
- 2025 – F. O. Butler à£à£Ö±²¥Ðã for Excellence in Research
- 2022 – William S. Wadsworth Jr. and Nancy Wadsworth Research Endowment à£à£Ö±²¥Ðã
Publications
Highlighted Publications:
- Jo S., Fischer BR, Cronin NM, Nurmalasari NPD, Loyd YM, Kerkvliet JG, Bailey EM, Anderson RB, Scott BL, Hoppe AD. Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis. Biophysical Journal. Aug. 6, 2024; 123(15):2312-2327. doi: 10.1016/j.bpj.2024.01.036. Epub Feb. 5, 2024. PMID: 38321740; PMCID: PMC11331046.
- Jo S., Fischer BR, Cronin NM, Nurmalasari NPD, Loyd YM, Kerkvliet JG, Bailey EM, Anderson RB, Scott BL, Hoppe AD. Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis. Biophysical Journal. Aug. 6, 2024; 123(15):2312-2327. doi: 10.1016/j.bpj.2024.01.036. Epub Feb. 5, 2024. PMID: 38321740; PMCID: PMC11331046.
- Hossain MS, Kerkvliet JG, Hoppe AD. Whole genome CRISPR screening strategy to identify genes contributing to SARS-CoV-2 spike and VSV-G mediated entry. Journal of Medical Virology. September 2023; 95(9):e29087. doi: 10.1002/jmv.29087. PMID: 37707319.
- Bailey EM, Choudhury A., Vuppula H., Ortiz DF, Schaeck J., Manning AM, Bosques CJ, Hoppe AD. Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes. Frontiers in Immunology. Feb. 15, 2021; 11:617767. doi: 10.3389/fimmu.2020.617767. PMID: 33679705; PMCID: PMC7928370.
