Dr. Benjamin Hause

Benjamin Hause

Adjunct Faculty

Biography

Dr. Ben Hause is virologist with a primary interest in emerging viruses associated with porcine and bovine disease. His research group focuses on the detection and characterization of these viruses and studies their role in à£à£Ö±²¥Ðã health. Dr. Hause spent a large part of his career in the veterinary vaccine industry and continues research and development of novel and efficacious vaccines for swine and cattle.

Education

  • Ph.D. in biological sciences | South à£à£Ö±²¥Ðã State University | 2013
  • M.S. in medical chemistry | University of Minnesota, Minneapolis | 2001
  • B.A. in chemistry and biology | University of Minnesota-Morris | 1998

Academic and Professional Experience

Work Experience
  • 2016 - 2020, Vice President of Research, Development and Diagnostics, Cambridge Technologies
  • 2015 - 2016, Clinical Assistant Professor, Department of Diagnostic. Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
  • 2014 - 2015, Assistant Research Professor, Department of Diagnostic. Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University
  • 2007 - 2014, Director, Diagnostic Services, Newport Laboratories
  • 2005 - 2007, Research Scientist, Newport Laboratories
  • 2001 - 2005, Research Scientist, Natureworks, LLC

Research and Scholarly Work

Patents
  1. 10,555,995. Hause B.M. Porcine pestivirus, vaccines and assays.
  2. 10,450,351. Hause B.M. Porcine circovirus 3 immunogenic compositions and methods of making and using the same.
  3. 9,623,105. Hause B.M. Attenuated swine influenza vaccines and methods of making and use thereof.
  4. 9,216,211. Hause B.M. Attenuated swine influenza vaccines and methods of making and use thereof.
  5. 9,446,117. Bey R.F., Simonson R.R., Sirigireddy K.R., Hause B.M. Rotavirus subunits vaccine and making and use thereof.
  6. 9,278,999. Simonson R.R., Hause B.M., Collin E.A. Influenza C virus and vaccines.
  7. 8,137,953. Miller M., Suominen P., Aristidou A., Hause B.M., Van Hoek P., Dundon C.A. Lactic acid producing yeast cells having non-functional L- or D-lactate:ferric cytochrome C oxidoreductase cells. November 17, 2006.
  8. 7,534,597. Hause B.M., Rajgarhia V., Suominen P., Methods and materials for the production of L-lactic acid in yeast. May 19, 2009.
Publications
  1. Hause B.M., Nelson E.A., Christopher-Hennings J. 2020. North American big brown bats harbor an exogenous Deltaretrovirus. mSphere 5(5):e00902-20.
  2. Gao R., Sreenivasan C.C., Sheng Z., Hause B.M., Zhou B., Wentworth D.E., Clement T., Rausch D., Brunick C., Christopher-Hennings J., Wu H., Bausch C.L., Sullivan E.J., Hoppe A.D., Huber V.C., Wang D., Li F. 2020. Human monoclonal antibody derived from transchromosomic (Tc) cattle neutralizes multiple H1 clades of influenza A virus by recognizing a novel conformational epitope in the HA head domain. Journal of Virology DOI: 10.1128/JVI.00945-20.
  3. Salem E., Dhanasekaran V., Cassard H., Hause B.M., Maman S., Meyer G., Ducatez M.F. 2020. Global transmission, spatial segregation and recombination determine the long-term evolution and epidemiology of bovine coronaviruses. Viruses 12(5):534.
  4. Franzo G., Delwart E., Fux R., Hause B.M., Su S., Zhou J., Segales J. 2020. Genotyping porcine circovirus 3 (PCV-3) nowadays: does it make sense? Viruses 12, 265; DOI:10.3390/v12030265.
  5. Oliva J., Mettier J., Sedano L., Delverdier M., Bourgés-Abella N., Hause B.M., Loupias J., Pardo I., Bleuart C., Bordignon P.J., Meunier E., Le Goffic R., Meyer G., Ducatez M.F. 2019. A murine model for the study of influenza D virus. Journal of Virology DOI:10.1128/JVI.01662-19.
  6. Liu R., Sheng Z., Lin T., Sreenivasan C., Gao R., Thomas M., Druce J., Hause B.M., Kaushik R.S., Li F., Wang D. 2019. Genetic and antigenic characteristics of a human influenza C virus clinical isolate. Journal of Medical Virology DOI: 10.1002/jmv.25589.
  7. Dane H., Duffy C., Guelbenzu M., Hause B.M., Fee S., Forster F., McMenamy M.J., Lemon K. 2019. Detection of influenza D virus in bovine respiratory disease samples, U.K. Transboundary and Emerging Diseases 66:2184-2187.
  8. Arruda B., Pineyro P., Derscheid R., Hause B.M., Byers E., Dion K., Long D., Sievers C., Tangen J., Williams T., Schwartz K. 2019. PCV3-associated disease in the United States swine herd. Emerging Microbes and Infection 8(1):684-698.
  9. Bauermann F.V., Hause B.M., Buysse A.R., Joshi L.R., Diel D.G. 2019. Identification and genetic characterization of a porcine hepe-astrovirus (bastrovirus) in the United States. Archives of Virology. DOI: 10.1007/s00705-019-04313-x.
  10. Sreenivasan C.C., Thomas M., Antony L., Wormstadt T., Hildreth M.B., Wang D., Hause B.M., Francis D.H., Li F., Kaushik R.S. 2019. Development and characterization of swine primary respiratory epithelial cells and their susceptibility to infection by four influenza virus types. Virology 528:152-163.
  11. Park J.Y., Welch M., Harmon K.M., Zhang J., Pineyro P.E., Li G., Hause B.M., Gauger P.C. 2018. Detection, isolation and in vitro characterization of porcine parainfluenza virus type 1 isolated from respiratory diagnostic specimens in swine. Veterinary Microbiology.
  12. Zhao W., Yu J., Thomas M., Sreenivasan C.C., Hause B.M., Wang D., Francis D.H., Kaushik R.S., Li F. 2018. . Veterinary Microbiology DOI: 10.1016/j.vetmic.2018.11.008.
  13. Wang Z., Huang B., Thomas M., Sreenivasan C.C., Sheng Z., Yu J., Hause B.M., Wang D., Francis D.H., Kaushik R.S., Li F. 2018. Detailed mapping of the linear B cell epitopes of the hemagglutinin (HA) protein of swine influenza virus. Virology 522:131-137.
  14. Thomas M., Pierson M., Uprety T., Zhu L., Ran Z., Sreenivasan C.C., Wang D., Hause B., Francis D.H., Li F., Kaushik R.S. 2018. Comparison of porcine airway and intestinal epithelial cell lines for the susceptibility and expression of pattern recognition receptors upon influenza virus infection. Viruses 10(6):E312. DOI:10.3390/v10060312.
  15. Hause B.M., Smith C., Bishop B., Stewart C., Simonson R. 2018. Complete genome sequence of a porcine polyomavirus from nasal swabs of pigs with respiratory disease. Genome Announc. 6(17).e00344-18.
  16. Flynn O., Gallagher C., Mooney J., Irvine C., Ducatez M., Hause B., McGrath G., Ryan E. 2018. Influenza D virus in cattle, Ireland. Emerging Infectious Diseases 24(2):389-391.
  17. Sreenivasan C.C., Jandhyala S.S., Luo S., Hause B.M., Thomas M., Knudsen D.E.B., Leslie-Steen P., Clement T., Reedy S.E., Chambers T.M., Christopher-Hennings J., Nelson E., Wang D., Kaushik R.S., Li F. 2018. Phylogenetic analysis and characterization of a sporadic isolate of equine influenza A H3N8 from an unvaccinated horse in 2015. Viruses 10(1):E31. DOI:10.3390/v10010031.
  18. Zhai S.L., Zhou X., Zhang H., Hause B.M., Lin T., Liu R., Chen Q.L., Wei W.K., Lv D.H., Wen X.H., Li F., Wang D. 2017. Comparative epidemiology of porcine circovirus type 3 in pigs with different clinical presentations. Virology Journal. 14:222.
  19. Arruda B., Arruda P., Hensch M., Chen Q., Zheng Y., Yang C., Gatto I.R.H., Ferreyra F.M., Gauger P., Schwartz K., Bradner L., Harmon K., Hause B.M., Li G. 2017. Porcine Astrovirus type 3 in central nervous system of swine with polioencephalomyelitis. Emerging Infectious Diseases 23:2097-2100.
  20. Mekata H., Yamamoto M., Hamabe S., Tanaka H., Omatsu T., Mizutani T., Hause B.M., Okabayashi T. 2017. Molecular epidemiological survey and phylogenetic analysis of bovine influenza D virus in Japan. Transboundary and Emerging Diseases 10.1111/tbed.12765.
  21. Yu J., Hika B., Liu R., Sheng Z., Hause B.M., Li F., Wang D. 2017. The hemagglutinin-esterase fusion glycoprotein is a primary determinant of the exceptional thermal and acid stability of influenza D virus. mSphere 2:e00254-17.
  22. Shang P., Misra S., Hause B., Fang Y. 2017. A naturally occurring recombinant enterovirus expresses a torovirus deubiquitinase. Journal of Virology JVI.00450-17.  Article featured as a Spotlight article based on significance.
  23. Arruda P.H., Arruda B.L., Schwartz K.J., Vannucci F., Resende T., Rovira A., Sundberg P., Nietfeld J., Hause B.M. 2017. Detection of a novel sapelovirus in central nervous tissue of pigs with polioencephalomyelitis in the U.S. Transboundary and Emerging Diseases 64:311-315.
  24. Zanin M., Duan S., Wong S.S., Kumar G., Baviskar P., Collin E., Russell C., Barman S., Hause B.M., Webby R. 2017. An amino acid in the stalk domain of N1 neuraminidase is critical for enzymatic activity. Journal of Virology 91:e00868-16.
  25. Palinski R.M., Pineyro P., Shang P., Yuan F., Guo R., Fang Y., Byers E., Hause B.M. 2016. A novel porcine circovirus distantly related to known circoviruses is associated with porcine dermatitis and nephropathy syndrome and reproductive failure. Journal of Virology JVI.01879-16. Article featured as a Spotlight article based on significance.
  26. Hause B.M., Huntimer L., Falkenberg S., Henningson J., Lechtenberg K., Halbur T. 2017. An influenza D virus vaccine protects cattle from respiratory disease caused by homologous challenge. Veterinary Microbiology 199:47-53.
  27. Murakami S., Endoh M., Kobayashi T., Takenaka-Uema A., Chambers J.K., Uchida K., Nishihara M., Hause B.M., Horimoto T. 2016. Influenza D virus infection in herd of cattle, Japan. Emerging Infectious Diseases 22:1517-1519.
  28. Hause B.M., Padmanabhan A., Pedersen K., Gidlewski T. 2016. The feral swine virome is dominated by single stranded DNA viruses and contains a novel orthopneumovirus which circulates both in feral and domestic swine. Journal of General Virology, DOI:10.1099/jgv.0.000554.
  29. Chen Z., Yuan F., Li Y., Shang P., Schroeder R., Lechtenberg K., Henningson J., Hause B.M., Bai J., Rowland R.R., Clavijo A., Fang Y. 2016. Construction and characterization of a full-length cDNA infectious clone of emerging Senecavirus A. Virology 497: 111-124.
  30. Vitosh-Sillman S., Loy J.D., Broderson B., Kelling C., Doster A., Topliff C., Nelson E., Bai J., Schirtzinger E., Poulsen E., Meadors B., Anderson J., Hause B.M., Anderson G., Hesse R. 2016. Experimental infection of conventional nursing pigs and their dams with porcine deltacoronavirus. Journal of Veterinary Diagnostic Investigation 28:486-497.
  31. Mitra N., Cernicchiaro N., Torres S., Li F., Hause B.M. 2016. Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus. Journal of General Virology, Epub May 5. DOI:10/1099/jgv.0.000492.
  32. Padmanabhan A., Hause B.M. 2016. Detection and characterization of a novel genotype of porcine astrovirus 4 from nasal swabs from pigs with acute respiratory disease. Archives of Virology, Epub 21 June: 10.007/s00705-016-2937-1.
  33. Hause B.M., Duff J.W., Scheidt A., Anderson G. 2016. Virus detection using metagenomic sequencing of swine nasal and rectal swabs. Journal of Swine Health and Production 24:304-308.
  34. Palinski R.M., Mitra N., Hause B.M. 2016. Discovery of a novel Parvovirinae virus, porcine parvovirus 7, by metagenomic sequencing of porcine rectal swabs. Virus Genes 52:564-567.
  35. Hause B.M., Myers O., Duff J., Hesse R.A. 2016. Senecavirus A in United States pigs, 2015. Emerging Infectious Diseases, 22:1323-1325.
  36. Jarvis M.C., Lam H.C., Zhang Y., Wang L., Hesse R.A., Hause B.M., Vlasova A., Wang Q., Zhang J., Nelson M.I., Murtaugh M.P., Marthaler D. 2015. Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus. Preventive Veterinary Medicine 123:175-184.
  37. Palinski R.M., Chen Z., Henningson J.N., Lang Y., Rowland R.R., Fang Y., Prickett J., Gauger P.C., Hause B.M. 2015. Widespread detection and characterization of porcine parainfluenza virus 1 in pigs in the United States. Journal of General Virology 97:281-286.
  38. Lindemann D.M., Carpenter J.W., Nietfeld J.C., Gonzalez E., Hallman M., Hause B.M. 2015. Multicentric T-cell lymphoma and cutaneous hemangiosarcoma in a captive cheetah (Acinonyx jubatus). Journal of Zoo and Wildlife Medicine 46(4):961-966.
  39. Schirtzinger E.E., Suddith A.W., Hause B.M., Hesse R.A. 2015. First identification of porcine parvovirus 6 in North America by viral metagenomic sequencing of serum from pigs infected with porcine reproductive and respiratory syndrome. Virology Journal 12:170.
  40. Sreenivasan C., Thomas M., Sheng Z., Hause B.M., Collin E.A., Knudsen D.E., Pillatzki A., Nelson E., Wang D., Kaushik R.S., Li F. 2015. Replication and transmission of novel bovine influenza D virus in guinea pig model. Journal of Virology pii:JVI.01630-15.
  41. Homwong N., Marthaler D., Convertino M., Torremorell M., Craft M., Hause B.M., Deen J. 2015. Bayesian estimation to test accuracy for influenza A infection via respiratory clinical signs in the absence of a gold standard. Journal of Veterinary Medicine and Animal Health 7(10):317-327.
  42. Hause B.M., Collin E.A., Peddireddi L., Yuan F., Chen Z., Hesse R.A., Gauger P.C., Clement T., Fang Y., Anderson G. 2015. Discovery of a novel putative atypical porcine pestivirus in pigs in the United States. Journal of General Virology DOI:10.1099/jgv.0.000251.
  43. Hause B.M., Hesse R.A., Anderson G.A. 2015. Identification of a novel Picornavirales virus distantly related to posavirus in swine feces. Virus Genes June 2.
  44. Tokarz R., Sameroff S., Hesse R.A., Hause B.M., Desai A., Jain K., Lipkin W.I. 2015. Discovery of a novel nidovirus in cattle with respiratory disease. Journal of General Virology DOI:10.1099/vir.0.000166.
  45. Collin E.A., Anbalagan S., Okda F., Batman R., Nelson E., Hause B.M. 2015. An inactivated vaccine made from a U.S. field isolate of porcine epidemic diarrhea virus is immunogenic in pigs as demonstrated by a dose titration. BMC Veterinary Research 11:62.
  46. Hause B.M., Collin E.A., Anderson J., Hesse R.A., Anderson G. 2015. Bovine rhinitis viruses are common in U.S. cattle with bovine respiratory disease. PLoS ONE 10:e0121998.
  47. Zanin M., Marathe B., Wong S.S., Yoon S.W., Collin E.A., Oshansky C., Hause B.M., Webby R.J. 2015. Pandemic swine H1N1 influenza viruses with almost undetectable neuraminidase activity do not transmit via aerosols in ferrets and are inhibited by mucus. Journal of Virology 89:5935-5948.
  48. Ran Z., Shen H., Lang Y., Kolb E.A., Turan N., Zhu L., Ma J., Bawa B., Liu Q., Liu H., Quast M., Sexton G., Krammer F., Hause B.M., Christopher-Hennings J., Nelson E.A., Richt J., Li F., Ma W. 2015. Domestic pigs are susceptible to infection with influenza B viruses. Journal of Virology 89:4818-4826.
  49. Thomas M., Wang Z., Sreenivasan C.C., Hause B.M., Gourapura R., Li F., Francis D.H., Kaushik R.S., Khatri M. 2015. Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigs. Vaccine 33(4):542-548.
Mailing Address:
Animal Disease Research 121
Animal Disease Research-Box 2175
University Station
Brookings, SD 57007
Office Location:
Animal Disease Research and Diagnostic Laboratory
Room 121
View Location
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Associated Areas
Students gather around cow skeleton as professor points to a bone in the neck
Department of Veterinary and Biomedical Sciences