Structural Biology, Bioinformatics and Systems Approaches Researchers
Fathi Halaweish
My group conducts research on the structural, synthetic and medicinal chemistry of natural products, including modeling and synthesis of drug-like analogs for therapeutic applications. Our research has produced several cancer chemotherapeutic candidates targeting liver, lung, colon, pancreas, prostate, ovarian and cervical, melanoma, breast cancer and drug candidates for other diseases, such as type 2-diabetes.
Suvobrata Chakravarty
My lab focuses on understanding how proteins interact with other molecules (i.e., other proteins, DNA, RNA etc.) using bioinformatics, biophysical chemistry and structural biology to discover how natural germline and somatic mutations impact human protein function. In t his research pursuit, we have developed: (a) experimental tools for rapid determination of affinity of protein–protein interactions, (b) algorithms for the study of weak molecular interactions, (c) analysis procedures for the study of specific protein interactions, (d) procedures for genome-scale analysis of mutations.
The Roux lab seeks to understand the structure and function of the nuclear envelope in health and disease and to uncovering the underlying mechanisms of nuclear envelopathies. In response to barriers in his research on the nuclear envelope, Dr. Kyle Roux established a method called BioID to screen for protein proximity and interactions in living cells, thus overcoming several limitations intrinsic to conventional approaches. Since it is uniquely capable of screening for protein associations in living cells, BioID is rapidly becoming an established method used by the scientific community.
